Surapaneni, Sekhar: search on Z-Library

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1

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || A Robust Methodology for Rapid Structure Determination of Microgram-Level Drug Metabolites by NMR Spectroscopy

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 226 KB

english, 2012

2

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Applications of Quantitative Whole-Body Autoradiography (QWBA) in Drug Discovery and Development

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 335 KB

english, 2012

3

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Supercritical Fluid Chromatography

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 154 KB

english, 2012

4

Role of drug metabolism in drug discovery and development

Gondi N. Kumar, Sekhar Surapaneni

Journal:

Medicinal Research Reviews

Year:

2001

Language:

english

File:

PDF, 300 KB

english, 2001

5

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Current Technology and Limitation of LC-MS

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 196 KB

english, 2012

6

The co-crystal approach to improve the exposure of a water-insoluble compound: AMG 517 sorbic acid co-crystal characterization and pharmacokinetics

Annette Bak, Anu Gore, Evelyn Yanez, Mary Stanton, Sunita Tufekcic, Rashid Syed, Anna Akrami, Mark Rose, Sekhar Surapaneni, Tracy Bostick, Anthony King, Sesha Neervannan, Drazen Ostovic, Arun Koparkar

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 591 KB

english, 2008

7

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Applications of iRNA Technologies in Drug Transporters and Drug Metabolizing Enzymes

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 382 KB

english, 2012

8

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Genetically Modified Mouse Models in ADME Studies

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 151 KB

english, 2012

9

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || In vitro Testing of Proarrhythmic Toxicity

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 76 KB

english, 2012

10

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Milk Excretion and Placental Transfer Studies

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 173 KB

english, 2012

11

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Tools and Strategies for the Assessment of Enzyme Induction in Drug Discovery and Development

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 208 KB

english, 2012

12

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Appendix: Drug Metabolizing Enzymes and Biotransformation Reactions

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 258 KB

english, 2012

13

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Chromatographic Separation Methods

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 211 KB

english, 2012

14

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Human Bile Collection for ADME Studies

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 225 KB

english, 2012

15

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Pluripotent Stem Cell Models in Human Drug Development

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 54 KB

english, 2012

16

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Radioactivity Profiling

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 188 KB

english, 2012

17

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Applications of Accelerator Mass Spectrometry (AMS)

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 109 KB

english, 2012

18

ChemInform Abstract: Role of Drug Metabolism in Drug Discovery and Development

Gondi N. Kumar, Sekhar Surapaneni

Journal:

Year:

2001

File:

PDF, 24 KB

2001

19

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Target Engagement for PK/PD Modeling and Translational Imaging Biomarkers

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 210 KB

english, 2012

20

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Radiosynthesis for ADME Studies

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 110 KB

english, 2012

21

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Mass Spectrometric Imaging for Drug Distribution in Tissues

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 382 KB

english, 2012

22

Pharmacokinetics, metabolism and excretion of [14C]-lenalidomide following oral administration in healthy male subjects

Nianhang Chen, Lian Wen, Henry Lau, Sekhar Surapaneni, Gondi Kumar

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 434 KB

english, 2012

23

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Methods for Assessing Blood-Brain Barrier Penetration in Drug Discovery

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 85 KB

english, 2012

24

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Reaction Phenotyping

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 278 KB

english, 2012

25

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Pharmacogenomics and Individualized Medicine

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 107 KB

english, 2012

26

Cytochrome P450-Mediated Epoxidation of 2-Aminothiazole-Based AKT Inhibitors: Identification of Novel GSH Adducts and Reduction of Metabolic Activation through Structural Changes Guided by in Silico and in Vitro Screening

Subramanian, Raju, Lee, Matthew R., Allen, John G., Bourbeau, Matthew P., Fotsch, Christopher, Hong, Fang-Tsao, Tadesse, Seifu, Yao, Guomin, Yuan, Chester C., Surapaneni, Sekhar

Journal:

Chemical Research in Toxicology

Year:

2010

Language:

english

File:

PDF, 1.56 MB

english, 2010

27

Excretion balance and pharmacokinetics following a single oral dose of [14C]-fedratinib in healthy subjects

Ogasawara, Ken, Xu, Christine, Kanamaluru, Vanaja, Siebers, Nicholas, Surapaneni, Sekhar, Ridoux, Laurence, Palmisano, Maria, Krishna, Gopal

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2020

File:

PDF, 759 KB

2020

28

[IEEE 2010 IEEE Network Operations and Management Symposium - NOMS 2010 - Osaka, Japan (2010.04.19-2010.04.23)] 2010 IEEE Network Operations and Management Symposium - NOMS 2010 - DReaM-Cache: Distributed Real-Time Transaction Memory Cache to support two-factor authentication services and its reliability

Qian, Haiyang, Surapaneni, Chandra Sekhar, Ray, Marsh, Dispensa, Stephen, Medhi, Deep

Year:

2010

Language:

english

File:

PDF, 399 KB

english, 2010

29

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Techniques for Determining Protein Binding in Drug Discovery and Development

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 194 KB

english, 2012

30

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Improving the Pharmaceutical Properties of Biologics in Drug Discovery: Unique Challenges and Enabling Solutions

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 124 KB

english, 2012

31

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Fast and Reliable CYP Inhibition Assays

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 418 KB

english, 2012

32

Disposition, metabolism and mass balance of [ 14 C]apremilast following oral administration

Hoffmann, Matthew, Kumar, Gondi, Schafer, Peter, Cedzik, Dorota, Capone, Lori, Fong, Kei-Lai, Gu, Zheming, Heller, Dennis, Feng, Hao, Surapaneni, Sekhar, Laskin, Oscar, Wu, Anfan

Journal:

Year:

2011

Language:

english

File:

PDF, 1.05 MB

english, 2011

33

The interactions of lenalidomide with human uptake and efflux transporters and UDP-glucuronosyltransferase 1A1: lack of potential for drug–drug interactions

Zeen Tong,Usha Yerramilli,Sekhar Surapaneni…

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2014

Language:

english

File:

PDF, 408 KB

english, 2014

34

Increased cellular accumulation and distribution of amrubicin contribute to its activity in anthracycline-resistant cancer cells

Vidya Mamidipudi, Tao Shi, Helen Brady, Sekhar Surapaneni, Rajesh Chopra, Sharon L. Aukerman, Carla Heise, Victoria Sung

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 725 KB

english, 2012

35

Enhanced Bioavailability of a Poorly Soluble VR1 Antagonist Using an Amorphous Solid Dispersion Approach: A Case Study

Kennedy, Michael, Hu, Jack, Gao, Ping, Li, Lan, Ali-Reynolds, Alana, Chal, Ben, Gupta, Vicki, Ma, Chandra, Mahajan, Nidhi, Akrami, Anna, Surapaneni, Sekhar

Journal:

Molecular Pharmaceutics

Year:

2008

Language:

english

File:

PDF, 309 KB

english, 2008

36

Application of a “Fit for Purpose” PBPK Model to Investigate the CYP3A4 Induction Potential of Enzalutamide

Narayanan, Rangaraj, Hoffmann, Matthew, Kumar, Gondi, Surapaneni, Sekhar

Journal:

Drug Metabolism Letters

Year:

2016

Language:

english

File:

PDF, 1.56 MB

english, 2016

37

In Vitro Inhibition of Human Nucleoside Transporters and Uptake of Azacitidine by an Isocitrate Dehydrogenase-2 Inhibitor Enasidenib and Its Metabolite AGI-16903

Tong, Zeen, Yerramilli, Usha, Yao, Sylvia, Young, James D., Hoffmann, Matthew, Surapaneni, Sekhar

Journal:

Year:

2018

Language:

english

File:

PDF, 1.03 MB

english, 2018

38

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Front Matter

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 191 KB

english, 2012

39

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Overview of Drug Metabolism and Pharmacokinetics with Applications in Drug Discovery and Development in China

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 182 KB

english, 2012

40

In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism

Atsriku, Christian, Hoffmann, Matthew, Moghaddam, Mehran, Kumar, Gondi, Surapaneni, Sekhar

Journal:

Year:

2015

Language:

english

File:

PDF, 1.41 MB

english, 2015

41

Assessment of Drug-Drug Interaction Potential and PBPK Modeling of CC-223, a Potent Inhibitor of the Mammalian Target of Rapamycin Kinase

Tong, Zeen, Narayanan, Rangaraj, Atsriku, Christian, Nissel, Jim, Li, Yan, Liu, Hong, Wang, Xiaomin, Surapaneni, Sekhar

Journal:

Year:

2018

Language:

english

File:

PDF, 1.13 MB

english, 2018

42

Evaluation of iberdomide and cytochrome p450 drug-drug interaction potential in vitro and in a phase 1 study in healthy subjects

Gaudy, Allison, Atsriku, Christian, Ye, Ying, MacGorman, Kimberly, Liu, Liangang, Xue, Yongjun, Surapaneni, Sekhar, Palmisano, Maria

Journal:

European Journal of Clinical Pharmacology

Year:

2020

File:

PDF, 926 KB

2020

43

Stereoselective metabolism of tazofelone, an anti-inflammatory bowel disease agent, in rats and dogs and in human liver microsomes

Michael P. Clay, Brenda R. Hanssen, Sekhar S. Surapaneni, Terry D. Lindstrom

Journal:

Year:

1999

Language:

english

File:

PDF, 181 KB

english, 1999

44

A preliminary pharmacokinetic study of the enantiomers of the terfenadine acid metabolite in humans

Sekhar Surapaneni, Dr. Shoukry K. W. Khalil

Journal:

Year:

1994

Language:

english

File:

PDF, 415 KB

english, 1994

45

In vitro assessment of cytochrome P450 inhibition and induction potential of azacitidine

Yong Chen, Lisa Liu, Eric Laille, Gondi Kumar, Sekhar Surapaneni

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2010

Language:

english

File:

PDF, 242 KB

english, 2010

46

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Animal Models for Studying Drug Metabolizing Enzymes and Transporters

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 191 KB

english, 2012

47

ADME-Enabling Technologies in Drug Design and Development (Zhang/ADME Technologies) || Formulation Development for Preclinical in vivo Studies

Zhang, Donglu, Surapaneni, Sekhar

Year:

2012

Language:

english

File:

PDF, 143 KB

english, 2012

48

Use of 4β-hydroxycholesterol in animal and human plasma samples as a biomarker for CYP3A induction

Xue, Y-J, Hoffmann, Matthew, Tong, Zeen, Wu, Xinqun (Irene), Vallejo, Martha, Melo, Brian, Ye, Ying, Thomas, Michael, Liu, Yong, Weiss, Daniel, Surapaneni, Sekhar

Journal:

Year:

2016

Language:

english

File:

PDF, 1.04 MB

english, 2016

49

Design and Synthesis of Peripherally Restricted Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists

Tamayo, Nuria, Liao, Hongyu, Stec, Markian M., Wang, Xianghong, Chakrabarti, Partha, Retz, Dan, Doherty, Elizabeth M., Surapaneni, Sekhar, Tamir, Rami, Bannon, Anthony W., Gavva, Narender R., Norman,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 336 KB

english, 2008

50

Metabolism and disposition of a potent and selective JNK inhibitor [ 14 C]tanzisertib following oral administration to rats, dogs and humans

Atsriku, Christian, Hoffmann, Matthew, Ye, Ying, Kumar, Gondi, Surapaneni, Sekhar

Journal:

Year:

2015

Language:

english

File:

PDF, 873 KB

english, 2015

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